Piroxicam Intermediate
Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties.
As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.
Intermediates
Product Specifications:
| Synonyms | Felden, Dexicam, Roxenan, and Others |
| Molecular Formula | C15H13N3O4S |
| Molecular Weight | 331.3 g/mol |
| Appearance | White Crystalline Solid |
| Solubility | Water, Dilute Acid, and Most Organic Solvents. |
| Assay | 93% |
Uses:
Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Piroxicam is in a class of medications called NSAIDs.